27 Mar 2008 Cyber Infrastructure is the chief enabler for innovation in many of today's most pressing Science and Engineering problems. There are in fact complete areas in Science such as Systems Biology that would not exist if not for a flourishing computing and information discipline. In this presentation we will introduce cyber infrastructure (CI), its chief components, and the transition from being an enhancer for discovery to an enabler. We will then introduce Cyber Communities as a viable way to build new CI for domain sciences. We will show through example and demonstration few existing projects in the Cyber Center at Purdue where high performance computing, hub technologies, data analytics and visualization all come together to solve specific problems. Elmagarmid, A.K