Jean-Marie Pagès

Address UMR-MD1, Faculté de Médecine, 27 Bd Jean Moulin, 13385 Marseille cedex 05, France. jean-marie.pages@univ-amu.fr Education/Academic degrees PhD Microbiology Biochemistry 1975. Doctorat Es-Sciences 1983 University de la Méditerranée, Marseille, France Position • 2009, Senior Director of Research (DR1) INSERM • 2012, Director of UMR-MD1 Research Unit “Membrane Transporters, Chemoresistance and Drug design” (University-Ministry of Defense). Scientific Committee and Memberships • Member of Scientific Committee on Emerging and Newly Identified Health Risks, EC-DG SANCO • Expert for NSF-USA and NIH-USA, Natural Sciences and Engineering Research Council, Canada, Singapour-National Medical Research Council, 7th PCRDT EC • Member of the Scientific Committee Synchrotron Soleil, Gif/Yvette, France • Member of the Scientific Committee Instituto de Higiene e Medicina Tropical, Lisboa, Portugal European research network • Chair of COST Action BM0701 “ Antibiotic transport and efflux: New strategies to combat bacterial resistance “• European IMI-ND4BB “ Molecular basis of the bacterial cell wall permeability “ 2013-2018. • European ITN-Marie Curie, “ Translocation “ 2013-2017. Science Societies • American Society for Microbiology and Société Française de Microbiologie • Referee for: Nature Med., J. Mol. Biol., Antimicrob. Agents Chemother., etc Honors • Astra/Zeneca/ESMID Wall of resistance Research Grant 2002 “An Analysis of In Vivo Activity of Efflux Pump Inhibitors in Antibiotic-Resistant Enterobacter Aerogenes” • Eloi Collery Prix, National Academy of Medicine, France 2005, “Bacterial membrane and antibiotic resistance mechanisms • Honor Medal of Health Dept. of French Army, 2010 Research Interest • Bacterial membrane transporters, drug efflux pumps (genetic, structural and functional aspects, structural-activity relationship) • Antibiotic resistance mechanisms in bacteria, mechanism-biochemistry, regulation and expression, activity and clinical involvement • New antimicrobial compounds, new target bypassing resistance mechanism Publications and Conferences over 300 scientific publications, abstracts, patents, lectures and communications in bacteriology-biochemistry-chemistry field Some publications: •Pagès et al. The porin and the permeating molecule: a selective diffusion barrier in Gram-negative bacteria. Nature Reviews Microbiology 2008, 6: 893-903. •Tran et al. Functional approach of porin channel: Antibiotic pathway through Providencia porins. J. Biol. Chem. 2010, 285: 32273-81. •Nikaido and Pagès. Broad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteria. FEMS Microbiol. Rev. 2012, 36:340-363. •Kaščáková et al. Antibiotic Transport in Resistant Bacteria: Synchrotron UV Fluorescence Microscopy to Determine Antibiotic Accumulation with Single Cell Resolution. PloS ONE 2012, 7(6): e38624. • Cinquin et al. Microspectrometric insights on the uptake of antibiotics at the single bacterial cell level. Sci. Reports, 2015, 5, 17968. Lectures (Invitation) • Pagès J.M. Bacterial transporters: the Pandora box of antibiotic resistance. 462nd WE Heraeus Seminar and BM0701 5th MCM-WG meeting, Bremen, Germany, 2010. • Pagès J.M. Modulation of membrane permeability: an efficient response to stress. 21st ECCMID-ICC, Milan, Italy, 2011. • Pagès J.M. Strategies for bypassing the membrane barrier in multidrug resistant Gram-negative organisms. AstraZeneca Infection IMED Annual Infection Symposium. Waltham, Boston, US, 2011. •Pagès J.M. Clinical and in vitro data regarding drug influx - efflux pump occurrence in Gram-negative bacteria, Gordon Research Conferences Multi-Drug Efflux Systems, Ventura, USA 2013. •Pagès J.M. Influx versus Efflux, the accumumation paradigm in Gram negative bacteria: an endless story. ITN-IMI Summer Conferences, Jacobs University, Bremen, Germany, 2015.